|
KMID : 1132720190170030023
|
|
Genomics & Informatics
2019 Volume.17 No. 3 p.23 ~ p.23
|
|
|
Identification of neoantigens derived from alternative splicing and RNA modification
|
|
Park Ji-Yeon
Chung Yeun-Jun
|
|
|
Abstract
|
|
|
|
The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.
|
|
|
KEYWORD
|
|
|
alternative splicing, neoantigen, RNA editing
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|